Journal of Biological Chemistry
Volume 296, January–June 2021, 100701
Research ArticleInhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
Under a Creative Commons license
open access
Keywords
ambroxol
SARS-CoV-2
acid sphingomyelinase
ceramide
infection
human nasal epithelial cells
Abbreviations
ACE2
angiotensin-converting enzyme 2
ATCC
American Type Culture Collection
COVID-19
coronavirus disease 2019
DMEM
Dulbecco's modified Eagle's medium
DTPA
diethylenetriaminepentaacetic acid
eGFP
enhanced GFP
FCS
fetal calf serum
FIASMAs
functional inhibitors of the acid sphingomyelinase
H/S
Hepes/saline
MEM
minimum essential medium
NP-40
Nonidet P40
OGP
n-octyl-d-glucopyranoside
PFA
paraformaldehyde
pp-VSV-SARS-CoV-2
vesicular stomatitis virus pseudoviral particles presenting SARS-CoV-2 spike protein on their surface
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
TMPRSS2
transmembrane serine protease 2
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© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.